NCPE resubmission and revised offer
Rebuilt the clinical and budget impact case for an NCPE resubmission, then supported the revised commercial offer.
Evidaxia is an independent market access, HTA and HEOR consultancy for the UK, Ireland and Europe. We build the economic case, the evidence base and the value story for HTA bodies, payers and funders, led by a former NICE HTA Technical Lead and Analyst.




Led by a former NICE HTA Technical Lead and Analyst, who knows how committees read a submission.
NICE, SMC, AWMSG, NCPE, CDA‑AMC and the EU JCA, plus US pricing work.
The person who scopes your project builds the model and joins the meeting.
More than a decade across clinical practice, public health, agencies and HTA.
Pick the challenge closest to yours.





Each practice can work on its own, or alongside the others on the same product or programme.

Cost-effectiveness and budget impact modelling, systematic reviews, indirect treatment comparisons, statistics and real-world evidence.
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NICE, SMC, AWMSG, NCPE and CDA-AMC submissions, EU JCA dossiers, pricing and reimbursement strategy, value communication and policy.
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Advisory boards, portfolio and indication prioritisation, early HTA advice, access due diligence for investors and in-house training.
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Health policy analysis, public affairs, health communications, advocacy and campaigns for companies, NGOs, governments and patient groups.
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Situation analysis, MEAL, programme costing, return on investment, advocacy and campaigns for NGOs, INGOs, donors and governments.
ExploreOur deepest experience is in oncology, haematology and cell therapy, and rare disease, with work across chronic, women's health and MedTech settings.
Explore therapy areasRebuilt the clinical and budget impact case for an NCPE resubmission, then supported the revised commercial offer.
PICO scoping, indirect treatment comparisons and network meta-analyses for JCA dossiers across several companies.
HTA Technical Lead and Analyst on appraisals in ophthalmology, hepatology, cardio-renal, haematology, and cell and gene therapy.
International price referencing analysis to show how MFN policy could move net prices across markets.
Cost-effectiveness and budget impact models adapted for UK, Irish, EU, Canadian and US settings in Excel/VBA, R and Python.
Programme design, monitoring, research and evaluation with UN agencies, international NGOs and research institutions.
Client names and products are confidential. See all our work.

Hasan Bari founded Evidaxia after more than a decade in healthcare: HTA Technical Lead and Analyst at NICE, agency roles as research manager, account director and programme management specialist, and public health roles with UNICEF headquarters, WHO, UNFPA and USAID.
How the Cancer Drugs Fund and Innovative Medicines Fund work in 2026: NICE managed access entry criteria, data collection agreements and CDF exit.
Read the analysisNICE technology appraisal in 2026: the STA process end to end, the new £25,000 to £35,000 threshold, severity weights, EQ-5D-5L and the MHRA-NICE pathway.
Read the analysisNICE EQ-5D-5L value set explained: PMG51 rules, 3L to 5L mapping, how utilities, ICERs and severity shortfall move, transition dates and evidence planning.
Read the analysisA practitioner guide to SMC submissions in 2026: NDC and SMC Committee, NPAF v4.0, PACE, ultra-orphan, interim acceptance, PASAG and decision data.
Read the analysisHow AWMSG works in 2026: when Wales follows NICE, panel routing, full, interim and limited assessment, CASWG commercial arrangements and budget impact.
Read the analysisThe Irish medicines reimbursement journey in 2026: the 2013 Act, NCPE assessment, HIQA methods, €20,000 and €45,000 per QALY, FASPM timelines and HSE decisions.
Read the analysisUS MFN drug pricing explained: GLOBE, GUARD and GENEROUS, reference baskets, the GDP (PPP) adjuster and what it means for UK, Irish and EU launch prices.
Read the analysisHow PICO scoping works in the EU joint clinical assessment, what the first published JCA reports show, and how to plan SLRs and indirect comparisons for it.
Read the analysisNICE severity modifier explained: absolute and proportional QALY shortfall, the 1.2 and 1.7 weights, a worked example and the 2026 EQ-5D-5L changes.
Read the analysisPopulation-adjusted indirect comparisons for HTA: how MAIC, STC and ML-NMR work, what NICE TSD 18 and the EU JCA guidelines require, and how to choose a method.
Read the analysisHow NICE and EU JCA evidence requirements align and diverge, and how to design one SLR and indirect treatment comparison programme to serve both.
Read the analysisNCPE rapid review vs full HTA explained: what triggers a full assessment, HIQA 2025 methods, the €20,000 and €45,000 thresholds, and the HSE decision process.
Read the analysisHow SMC and AWMSG assess new medicines: PACE, modifiers, ultra-orphan and interim acceptance, PASAG, Wales commercial arrangements, and differences from NICE.
Read the analysisSurvival extrapolation for HTA: NICE DSU TSD 14 and TSD 21, hazard plots, spline and cure models, external data, treatment effect waning and immature data.
Read the analysisHow to adapt a global cost-effectiveness model for NICE and NCPE: reference cases, discounting, EQ-5D, local costs, severity, budget impact and validation.
Read the analysisWhen and how to update a systematic literature review for HTA: BMJ consensus, Cochrane and PRISMA guidance, NICE and EU JCA search rules, living SLRs and AI.
Read the analysisHTA and payer decisions for GLP-1 obesity medicines across the US, England, France, Germany and Ireland.
Read the analysisWhich EU member states are ready for joint clinical assessment, and what that means for 2027 launches.
Read the analysisOnly one of eleven major HTA bodies has a full position statement on AI in evidence generation.
Read the analysisEvidaxia is an independent health economics, market access and global health consultancy. We build economic models and evidence packages, prepare HTA and EU JCA submissions, support pricing and reimbursement, and help NGOs, charities and public health programmes measure and communicate their impact.
Our founder worked inside NICE as an HTA Technical Lead and Analyst, so we build evidence the way assessors read it. The senior person who scopes your project does the work, from the first model to the final meeting.
Yes. We support NICE, SMC, AWMSG, NCPE, CDA-AMC and EU JCA work, from early advice and PICO scoping to the dossier, clarification questions, resubmission and price negotiation.
Our work spans oncology, rare diseases, cell and gene therapy, cardiovascular, ophthalmology, respiratory, haematology and women's health, for medicines, advanced therapies, devices, diagnostics and digital health.
Yes. We help them with situation analysis, MEAL, costing, return on investment, advocacy and campaigns. We also take on pro bono partnerships with selected community organisations, charities and patient groups.
Every project starts with a free, no-obligation 30-minute call about the decision ahead. We then agree the scope, deliverables and timelines before work starts, and the senior consultant who scopes the work delivers it.
Yes. We provide policy analysis and benchmarking, stakeholder mapping, public affairs, policy briefs and consultation responses, health communications, media relations and advocacy campaigns, for companies, NGOs, governments and patient groups.
We are based in the EU and work across the UK, Ireland, Europe, Canada and the US, and with global health programmes in low- and middle-income countries.
Bodies, perspectives, discount rates and value logic, side by side.
Learn moreEvidence submissions, models and committee preparation for England, Scotland and Wales.
Learn moreSTA and HST submissions, the 2026 threshold and managed access.
Learn moreFull, abbreviated and resubmissions, PACE and ultra-orphan routes.
Learn moreAWTTC assessment, limited assessments and WPAS, under the 2025 process.
Learn moreRapid review and full HTA submissions, built to HIQA methods.
Learn morePICO simulation, JCA-standard evidence and dossier writing.
Learn moreThe EU HTA Regulation at EU level and INAMI-RIZIV in Belgium.
Learn moreModule 1 to 5 dossiers, zVT strategy and the G-BA benefit assessment.
Learn moreTransparency Committee, SMR and ASMR, CEESP efficiency opinions.
Learn moreGVS, the lock procedure and Dutch economic evaluation.
Learn moreSweden, Norway, Denmark and Finland compared, plus JNHB.
Learn moreTLV reimbursement, NT council assessments and three-party talks.
Learn moreDMP single technology assessments and absolute shortfall.
Learn moreMedicinrådet applications, Danish methods and Amgros pricing.
Learn moreThe ANMDMR scorecard, CNAS contracts and Romanian pricing.
Learn moreCDA-AMC reviews, INESSS, pCPA and PMPRB.
Learn more“We needed a submission that would meet the committee's evidence standards on a tight timeline. The economic case was clear, the clinical arguments were grounded in the evidence, and clarification questions were answered quickly. The appraisal reached a positive recommendation.”
“Our NCPE rapid review had a short window and several open questions on the model. Evidaxia identified the key issues quickly and delivered a clean, fully documented submission. The process went more smoothly than I expected.”
“Joint clinical assessment is new territory for most teams, ours included. The PICO scoping was thoughtful, the indirect treatment comparisons and network meta-analysis were transparent, and the dossier was ready when we needed it. We went into the process with confidence.”
“We handed over a global model and got back a Canadian adaptation for CDA-AMC that was easy to audit and easy to explain to payers. Assumptions were documented, every change was traceable, and questions got direct answers.”
“The pricing analysis helped us decide where to focus and what to expect from international reference pricing. It gave the team a clear view of the trade-offs rather than a long list of options.”
“Having someone in the room who understands both how HTA bodies think and the economics behind their decisions made the advisory board far more useful. The advice was practical, and it changed how we planned our evidence generation.”
Client names are withheld at their request for confidentiality.
Health economics and outcomes research for HTA and payers.
Learn moreNICE, SMC, AWMSG, NCPE and EU JCA, from the assessor’s side.
Learn moreAccess strategy, pricing and value, from evidence to agreed price.
Learn morePICO simulation, JCA-standard evidence and dossier writing.
Learn moreUS most-favored-nation exposure and European launch pricing.
Learn moreClinical, economic, HRQoL and cost reviews for HTA.
Learn moreStart with a free, no-obligation 30-minute call with a senior consultant.